Endocrine Abstracts

Background: The plurihormonal pituitary adenomas represent 10-15% of all functioning pituitary adenoma. Mixed Growth hormone and prolactin secreting adenomas are the commonest one, approximately 5% of surgically removed adenoma. Other hormonal mixture of adenoma may occur, but very rare. We present a rare case of co-secreting TSH and GH adenoma. Clinical Case: A 45 year old gentleman, generally fit and well, presented with 3 years history of blurred visi...

Section 1: Case History: A 45-year-old gentleman attended the emergency department in December 2016 with an episode of stupor, confusion and lethargy with blood glucose of 1.8 mmol/l. He recovered after administration of IV glucose. He had ’funny spells’ for a year prior to the event. He had a history of childhood asthma and was not on any regular medications. There were no significant findings in the clinical examination and no relevant family history. <p class=...

Introduction: Primary hyperparathyroidism is usually caused by a parathyroid adenoma (80-85%), occasionally by primary parathyroid hyperplasia (10-15%), and rarely by atypical parathyroid tumor (APT) or carcinoma (<1%). APT reflects parathyroid neoplasm of uncertain malignant potential which poses a challenge for differential diagnosis with parathyroid carcinomas. Most patients exhibit strong symptomatology of hypercalcemia at presentation shared with the benign causes of ...

Introduction: Primary hyperparathyroidism may be sporadic or occur as part of a genetic predisposition. Inactivation of CDC73 tumour suppressor gene can cause hyperparathyroidism-jaw tumour (HPT-IJ) syndrome, parathyroid carcinoma or familial isolated hyperparathyroidism (FIHP).Case details: We report a 26 year old gentleman, previously fit and well who was found to have hypercalcemia on a routine testing. Renal ultrasou...

Introduction: Hashitoxicosis is the rare case of autoimmune thyroid disease. While transforming from Graves’ disease to spontaneous hypothyroid is well known, development of hyperthyroidism following hypothyroidism is a rare phenomenon which can pose a challenge in management. We report here a case of Hashitoxicosis managed with "Block and Replace Therapy" to maintain her euthyroid while waiting for definitive therapy.Case Report: A 30-year-...

Background: The Ultrasonography (USS) and Tc-SestaMiBi (MiBi) scans are established tests to localize parathyroid adenoma. It is important to utilize these appropriately prior to surgery for a positive outcome.Method: It was a retrospective study in patients diagnosed with primary hyperparathyroidism (PHPT) according to the NICE Guideline who underwent parathyroidectomy from 01/01/2015 to 31/12/2019. We aimed to assess the USS and Tc-Sestamibi scan’...